INSR

Across TCGA patient cohorts, INSR protein abundance is significantly associated with the RNA expression of many other genes, with 11,599 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible INSR-associated genes across cancer lineages are ZBED2, ADK, and RPL9P30. Each is linked with INSR in more than 4 cancer types. Because this analysis shows association rather than direction, both INSR-to-partner and partner-to-INSR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, INSR versus ZBED2 in HNSC, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSR→partner) and Y-score (partner→INSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZBED2 →	-1.023	-0.259	<.001	<.001	3	5
LUAD	ADK →	-0.596	-0.234	<.001	.003	3	4
UCEC	RPL9P30 →	+0.725	+0.336	.004	.002	3	4
UCEC	ZNF92 →	-0.753	-0.403	.001	.002	3	4
HNSC	NIP7 →	-0.553	-0.277	<.001	<.001	3	4
PDAC	SLC37A2 →	-0.726	-0.276	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,599 associations by consensus.

INSR vs ZBED2 — HNSC

Explore this scatter interactively →