INSR

Across TCGA patient cohorts, INSR mutation is significantly associated with the RNA expression of many other genes, with 4,327 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSR-associated genes across cancer lineages are ITPK1, LMO2, and ZNF660. Each is linked with INSR in more than 3 cancer types. Because this analysis shows association rather than direction, both INSR-to-partner and partner-to-INSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITPK1 grouped by INSR-low versus INSR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSR→partner) and Y-score (partner→INSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ITPK1 →	+0.532	+2.009	<.001	.001	3	4
SKCM	LMO2 →	-0.604	-1.980	.001	<.001	3	4
SKCM	ZNF660 →	-0.501	-3.794	.001	<.001	3	4
UCEC	TOMM22 →	+0.294	+1.343	.001	<.001	3	4
UCEC	SGTA →	+0.445	+1.895	<.001	<.001	3	4
UCEC	SAMD11 →	-0.715	-1.906	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,327 associations by consensus.

ITPK1 by INSR expression — SKCM

Explore this box plot interactively →