INSR

Across TCGA patient cohorts, INSR mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSR-associated genes across cancer lineages are ASNS, JNK_pT183_Y185, and MEK1. Each is linked with INSR in more than 3 cancer types. Because this analysis shows association rather than direction, both INSR-to-partner and partner-to-INSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by INSR-low versus INSR-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSR→partner) and Y-score (partner→INSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.498	+3.000	.029	.036	3	3
UCEC	JNK_pT183_Y185 →	-0.128	-1.401	.005	.002	3	3
UCEC	MEK1 →	+0.285	+1.432	.004	.004	3	3
SKCM	p38-MAPK_pT180_Y182 →	-0.326	-2.321	.030	.033	3	3
UCEC	p62 Lck ligand →	+0.392	+2.169	<.001	<.001	3	3
UCEC	p70-S6K_pT389 →	-0.119	-1.343	.021	.013	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ASNS by INSR expression — STAD

Explore this box plot interactively →