INSR

Across TCGA cell cohorts, INSR mutation is significantly associated with the RNA expression of many other genes, with 480 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INSR-associated genes across cancer lineages are NLRP8, UFSP2, and SPRR1A. Each is linked with INSR in more than 1 cancer types. Because this analysis shows association rather than direction, both INSR-to-partner and partner-to-INSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP8 grouped by INSR-low versus INSR-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSR→partner) and Y-score (partner→INSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NLRP8 →	+0.006	+4.906	<.001	.006	3	2
BLOOD_Leukemia	UFSP2 →	+0.493	+3.199	.008	.007	3	2
BLOOD_Leukemia	SPRR1A →	+0.120	+2.979	<.001	.007	3	2
BLOOD_Leukemia	RIMKLA →	+0.830	+3.199	<.001	.007	3	2
BLOOD_Leukemia	FAM110C →	+0.580	+3.455	.007	.004	3	2
BLOOD_Leukemia	C9orf57 →	+0.067	+2.450	.006	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 480 associations by consensus.

NLRP8 by INSR expression — OESOPHAGUS

Explore this box plot interactively →