INSM2

Across TCGA patient cohorts, INSM2 mutation is significantly associated with the RNA expression of many other genes, with 1,318 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSM2-associated genes across cancer lineages are HSPA4L, PBK, and CTDNEP1. Each is linked with INSM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both INSM2-to-partner and partner-to-INSM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPA4L grouped by INSM2-low versus INSM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSM2→partner) and Y-score (partner→INSM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPA4L →	+0.841	+3.711	<.001	<.001	3	3
UCEC	PBK →	+0.764	+3.258	.006	<.001	3	3
UCEC	CTDNEP1 →	+0.303	+2.617	.008	<.001	3	3
UCEC	TYMS →	+0.795	+2.584	.002	.001	3	3
UCEC	THAP3 →	+0.348	+3.491	.001	.002	3	3
UCEC	SHMT2 →	+0.580	+3.606	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,318 associations by consensus.

HSPA4L by INSM2 expression — UCEC

Explore this box plot interactively →