INSM2

Across TCGA cell cohorts, INSM2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INSM2-associated genes across cancer lineages are AVP, TPRX1, and OR5P2. Each is linked with INSM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both INSM2-to-partner and partner-to-INSM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by INSM2-low versus INSM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSM2→partner) and Y-score (partner→INSM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.059	+4.217	<.001	.001	3	2
BLOOD_Lymphoma	TPRX1 →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR5P2 →	+0.028	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
LARGE_INTESTINE	ZBBX →	+0.146	+3.777	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

AVP by INSM2 expression — LARGE_INTESTINE

Explore this box plot interactively →