INSL4

Across TCGA patient cohorts, INSL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,313 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible INSL4-associated GO terms across cancer lineages are Response to amine, CAMP catabolic process, and Regulation of prostaglandin secretion. Each is linked with INSL4 in more than 6 cancer types. Because this analysis shows association rather than direction, both INSL4-to-partner and partner-to-INSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to amine grouped by INSL4-low versus INSL4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INSL4→partner) and Y-score (partner→INSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Response to amine →	+0.053	+0.193	<.001	<.001	3	7
ESCA	CAMP catabolic process →	+0.061	+0.398	<.001	<.001	3	7
PCPG	Regulation of prostaglandin secretion →	+0.025	+0.010	.004	.002	3	6
LUAD	Negative regulation of relaxation of muscle →	+0.059	+1.242	<.001	<.001	3	5
ESCA	Response to corticotropin-releasing hormone →	+0.109	+0.313	<.001	.001	2	6
PCPG	CGMP catabolic process →	+0.043	+0.007	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,313 associations by consensus.

Response to amine by INSL4 expression — ESCA

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