INSL4

Across TCGA patient cohorts, INSL4 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSL4-associated genes across cancer lineages are GATA6, Di-Ras3, and MEK1. Each is linked with INSL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both INSL4-to-partner and partner-to-INSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by INSL4-low versus INSL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSL4→partner) and Y-score (partner→INSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.199	-2.992	.025	.036	3	1
UCEC	Di-Ras3 →	-0.184	-3.000	.032	.037	2	2
UCEC	MEK1 →	+0.521	+3.000	.013	.037	1	1
UCEC	TFRC →	+0.622	+3.000	.042	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GATA6 by INSL4 expression — UCEC

Explore this box plot interactively →