INSL3

Across TCGA pan-cancer cohorts, INSL3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated INSL3 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher INSL3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated INSL3 expression acts as an unfavorable survival marker.

BLCA, SKCM, and LUAD are the cancer types where INSL3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.212	0.720	.007	12	view →
SKCM	DFS	Median	All	0.207	0.728	.018	6	view →
LUAD	OS	Median	All	0.301	0.698	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

INSL3–BLCA (OS)

Open the BLCA breakdown →