INSL3

Across TCGA cell cohorts, INSL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,398 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible INSL3-associated GO terms across cancer lineages are Establishment of meiotic spindle orientation, Meiotic chromosome segregation, and Negative regulation of mitotic spindle assembly checkpoint signaling. Each is linked with INSL3 in more than 9 cancer types. Because this analysis shows association rather than direction, both INSL3-to-partner and partner-to-INSL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of meiotic spindle orientation grouped by INSL3-low versus INSL3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INSL3→partner) and Y-score (partner→INSL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Establishment of meiotic spindle orientation →	-0.131	-0.422	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Meiotic chromosome segregation →	-0.157	-0.365	<.001	.001	2	10
KIDNEY	Negative regulation of mitotic spindle assembly checkpoint signaling →	-0.187	-0.472	<.001	.009	3	8
LARGE_INTESTINE	Positive regulation of amyloid-beta formation →	+0.107	+0.267	.001	.008	3	8
KIDNEY	Negative regulation of spindle checkpoint →	-0.187	-0.472	<.001	.009	3	8
STOMACH	Attachment of mitotic spindle microtubules to kinetochore →	-0.108	-0.382	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,398 associations by consensus.

Establishment of meiotic spindle orientation by INSL3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →