INSL3

Across TCGA cell cohorts, INSL3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INSL3-associated genes across cancer lineages are PRAMEF20, CFHR2, and REM1. Each is linked with INSL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both INSL3-to-partner and partner-to-INSL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF20 grouped by INSL3-low versus INSL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSL3→partner) and Y-score (partner→INSL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
LARGE_INTESTINE	REM1 →	+0.049	+4.510	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PRAMEF20 by INSL3 expression — LARGE_INTESTINE

Explore this box plot interactively →