INSIG2

Across TCGA pan-cancer cohorts, INSIG2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated INSIG2 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher INSIG2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated INSIG2 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

GBM and LSCC are the cancer types where INSIG2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.498	0.787	.028	4	view →
LSCC	OS	Quartile	All	0.998	0.809	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

INSIG2–GBM (DFS)

Open the GBM breakdown →