INSIG2

Across TCGA patient cohorts, INSIG2 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,095 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible INSIG2-associated proteins across cancer lineages are PLOD2, LOXL2, and MRPL38. Each is linked with INSIG2 in more than 5 cancer types. Because this analysis shows association rather than direction, both INSIG2-to-partner and partner-to-INSIG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, INSIG2 versus PLOD2 in GBM, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (INSIG2→partner) and Y-score (partner→INSIG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLOD2 →	+0.920	+0.703	<.001	<.001	3	6
PDAC	LOXL2 →	+0.852	+0.562	<.001	<.001	3	5
COAD	MRPL38 →	-0.311	-0.410	<.001	<.001	2	5
COAD	MRPS22 →	-0.348	-0.454	.002	<.001	3	4
OV	MRPS35 →	-0.517	-0.677	<.001	<.001	3	4
COAD	MRPS9 →	-0.287	-0.467	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,095 associations by consensus.

INSIG2 vs PLOD2 — GBM

Explore this scatter interactively →