INSIG2

Across TCGA patient cohorts, INSIG2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,005 significant associations in total. GBM shows the largest number of these associations.

The most reproducible INSIG2-associated genes across cancer lineages are ZNF41, STC1, and BDH1. Each is linked with INSIG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both INSIG2-to-partner and partner-to-INSIG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, INSIG2 versus ZNF41 in GBM, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSIG2→partner) and Y-score (partner→INSIG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZNF41 →	-0.438	-0.524	<.001	<.001	3	2
GBM	STC1 →	+1.066	+0.414	.005	<.001	3	2
GBM	BDH1 →	-0.854	-0.428	<.001	.005	3	2
UCEC	ZKSCAN7 →	-0.797	-0.681	.006	.005	2	3
GBM	NPTXR →	-1.448	-0.464	.004	.005	3	2
OV	RPL12P4 →	-1.827	-0.784	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,005 associations by consensus.

INSIG2 vs ZNF41 — GBM

Explore this scatter interactively →