INSIG2

Across TCGA patient cohorts, INSIG2 protein abundance is significantly associated with the protein abundance of many other proteins, with 4,262 significant associations in total. GBM shows the largest number of these associations.

The most reproducible INSIG2-associated proteins across cancer lineages are DPM3, RTN3, and SEC11A. Each is linked with INSIG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both INSIG2-to-partner and partner-to-INSIG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, INSIG2 versus DPM3 in BRCA, with a Pearson correlation of 0.69.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (INSIG2→partner) and Y-score (partner→INSIG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DPM3 →	+1.006	+1.045	<.001	<.001	3	4
UCEC	RTN3 →	+0.672	+0.869	.001	<.001	3	3
UCEC	SEC11A →	+0.900	+0.743	<.001	.001	3	3
BRCA	SEC62_T158 →	+1.223	+0.783	<.001	<.001	3	3
BRCA	SSR3 →	+1.496	+1.251	<.001	.001	2	4
LUAD	ALG3_S13 →	+0.913	+0.527	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,262 associations by consensus.

INSIG2 vs DPM3 — BRCA

Explore this scatter interactively →