INSIG2

Across TCGA cell cohorts, INSIG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,585 significant associations in total. BONE shows the largest number of these associations.

The most reproducible INSIG2-associated GO terms across cancer lineages are SREBP signaling pathway, Maintenance of protein localization in organelle, and Response to sterol depletion. Each is linked with INSIG2 in more than 15 cancer types. Because this analysis shows association rather than direction, both INSIG2-to-partner and partner-to-INSIG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SREBP signaling pathway grouped by INSIG2-low versus INSIG2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INSIG2→partner) and Y-score (partner→INSIG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SREBP signaling pathway →	+0.133	+0.889	<.001	<.001	3	16
SOFT_TISSUE	Maintenance of protein localization in organelle →	+0.127	+0.936	<.001	<.001	3	14
CNS	Response to sterol depletion →	+0.131	+1.042	<.001	<.001	3	13
STOMACH	Cellular response to sterol depletion →	+0.126	+0.949	.003	.001	2	14
BREAST	Negative regulation of SREBP signaling pathway →	+0.193	+1.364	<.001	<.001	3	13
BONE	Regulation of proteolysis →	+0.112	+0.786	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,585 associations by consensus.

SREBP signaling pathway by INSIG2 expression — SKIN

Explore this box plot interactively →