Across TCGA patient cohorts, INSIG1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,416 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible INSIG1-associated proteins across cancer lineages are FDFT1, HMGCS1, and FASN. Each is linked with INSIG1 in more than 6 cancer types. Because this analysis shows association rather than direction, both INSIG1-to-partner and partner-to-INSIG1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (INSIG1→partner) and Y-score (partner→INSIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FDFT1 →	+0.739	+0.770	<.001	<.001	2	7
GBM	HMGCS1 →	+0.792	+0.707	<.001	<.001	3	5
UCEC	FASN →	+0.415	+0.771	.001	<.001	3	5
COAD	FDPS →	+0.432	+0.831	<.001	<.001	3	5
BRCA	LSS →	+0.321	+0.447	<.001	.002	3	5
BRCA	PTGES3_S148 →	+0.818	+0.558	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,416 associations by consensus.

Exploration

INSIG1 survival (RNA) · tumor vs normal (RNA) · all INSIG1 data types