Across TCGA patient cohorts, INSIG1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSIG1-associated genes across cancer lineages are GATA6, INPP4B, and PCNA. Each is linked with INSIG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both INSIG1-to-partner and partner-to-INSIG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSIG1→partner) and Y-score (partner→INSIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.125	-1.577	.039	.036	3	2
UCEC	INPP4B →	-0.360	-2.074	.003	.005	3	2
UCEC	PCNA →	+0.262	+2.087	.001	.005	3	2
UCEC	ATM →	-0.588	-3.584	<.001	.002	3	2
UCEC	14-3-3_beta →	-0.096	-3.295	.012	.009	3	1
UCEC	EGFR_pY1068 →	-0.239	-2.459	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

INSIG1 survival (RNA) · tumor vs normal (RNA) · all INSIG1 data types