INSIG1

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, INSIG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,058 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INSIG1-associated GO terms across cancer lineages are Maintenance of protein localization in endoplasmic reticulum, Isopentenyl diphosphate biosynthetic process, and Sterol biosynthetic process. Each is linked with INSIG1 in more than 18 cancer types. Because this analysis shows association rather than direction, both INSIG1-to-partner and partner-to-INSIG1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INSIG1→partner) and Y-score (partner→INSIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUNG_SCLCMaintenance of protein localization in endoplasmic reticulum →+0.166+1.823<.001<.001319
PANCREASIsopentenyl diphosphate biosynthetic process →+0.213+1.868<.001<.001317
BONESterol biosynthetic process →+0.248+2.341<.001<.001317
BONESecondary alcohol biosynthetic process →+0.254+2.340<.001<.001317
BONECholesterol biosynthetic process →+0.254+2.340<.001<.001317
LUNG_SCLCZymosterol metabolic process →+0.291+2.352<.001<.001317
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,058 associations by consensus.

Exploration