Across TCGA pan-cancer cohorts, INSC Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated INSC data layer compared with 21 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher INSC Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated INSC expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, UCEC, and SKCM are the cancer types where INSC Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.028	0.675	<.001	63	view →
UCEC	DFS	Median	All	0.948	0.619	.006	28	view →
SKCM	DFS	Median	III,IV	0.178	0.617	.004	6	view →
LGG	OS	Median	All	0.295	0.799	.007	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: INSC tumor-vs-normal RNA expression · all INSC data types