Across TCGA patient cohorts, INSC mutation is significantly associated with the RNA expression of many other genes, with 4,653 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSC-associated genes across cancer lineages are SNRPB, ALKBH1, and TMEM106C. Each is linked with INSC in more than 3 cancer types. Because this analysis shows association rather than direction, both INSC-to-partner and partner-to-INSC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSC→partner) and Y-score (partner→INSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPB →	+0.322	+1.557	.004	.001	3	4
UCEC	ALKBH1 →	+0.331	+1.779	<.001	<.001	3	3
LUAD	TMEM106C →	+0.665	+2.169	<.001	.003	3	3
LUAD	CDC25C →	+0.758	+3.816	<.001	<.001	3	3
LUAD	IFI27L1 →	+0.503	+3.368	<.001	.004	3	3
UCEC	LIG1 →	+0.457	+3.364	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,653 associations by consensus.

Exploration

INSC survival (RNA) · tumor vs normal (RNA) · all INSC data types