Across TCGA patient cohorts, INSC mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSC-associated genes across cancer lineages are p62 Lck ligand, JNK_pT183_Y185, and eEF2. Each is linked with INSC in more than 3 cancer types. Because this analysis shows association rather than direction, both INSC-to-partner and partner-to-INSC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSC→partner) and Y-score (partner→INSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p62 Lck ligand →	+0.478	+3.459	.012	.005	3	3
UCEC	JNK_pT183_Y185 →	-0.157	-1.584	.004	.034	3	3
COAD	eEF2 →	+0.330	+2.178	.017	.035	3	3
UCEC	PKC-b-II_pS660 →	-0.271	-1.459	.002	.012	3	3
LUAD	Syk →	-0.262	-2.115	.042	.018	3	2
UCEC	Cyclin-B1 →	+0.756	+2.321	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Exploration

INSC survival (RNA) · tumor vs normal (RNA) · all INSC data types