Across TCGA cell cohorts, INSC mutation is significantly associated with the mutation status of many other genes, with 4,494 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INSC-associated genes across cancer lineages are SYNRG, SNAP91, and ABCC9. Each is linked with INSC in more than 3 cancer types. Because this analysis shows association rather than direction, both INSC-to-partner and partner-to-INSC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSC→partner) and Y-score (partner→INSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SYNRG →	+4.334	+2.924	.006	.006	1	4
BLOOD_Leukemia	SNAP91 →	+5.479	+6.145	<.001	<.001	1	4
OVARY	ABCC9 →	+4.562	+5.217	<.001	<.001	1	4
BLOOD_Leukemia	PRICKLE2 →	+3.894	+5.247	.001	.001	1	4
BLOOD_Leukemia	BRWD3 →	+3.309	+4.794	.002	.002	1	4
LUNG_SCLC	SV2A →	+3.777	+3.307	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,494 associations by consensus.

Exploration

INSC survival (RNA) · tumor vs normal (RNA) · all INSC data types