Across TCGA cell cohorts, INSC mutation is significantly associated with the drug of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INSC-associated genes across cancer lineages are PD0325901, Trametinib, and GSK2801. Each is linked with INSC in more than 1 cancer types. Because this analysis shows association rather than direction, both INSC-to-partner and partner-to-INSC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSC→partner) and Y-score (partner→INSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PD0325901 →	-0.574	-2.745	.022	.047	3	1
LARGE_INTESTINE	Trametinib →	-0.669	-2.745	.033	.047	3	1
LARGE_INTESTINE	GSK2801 →	+0.338	+2.871	.024	.021	3	1
LARGE_INTESTINE	Oxaliplatin →	+0.538	+2.871	.032	.021	2	1
LARGE_INTESTINE	729189 →	+0.320	+2.871	.007	.021	2	1
LARGE_INTESTINE	CCT007093 →	+0.402	+2.649	.006	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

INSC survival (RNA) · tumor vs normal (RNA) · all INSC data types