INS

Across TCGA pan-cancer cohorts, INS mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated INS data layer compared with 20 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher INS mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated INS expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC are the cancer types where INS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	IV	0.951	0.381	.006	17	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

INS–PDAC (OS)

Open the PDAC breakdown →