INPPL1

Across TCGA pan-cancer cohorts, INPPL1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated INPPL1 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher INPPL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated INPPL1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where INPPL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.553	0.807	.014	15	view →
LUAD	DFS	Median	All	0.428	0.710	.014	6	view →
LSCC	OS	Median	All	0.793	1.000	.025	6	view →
PDAC	DFS	Median	II,III,IV	0.302	0.508	.022	5	view →
CCRCC	DFS	Quartile	All	0.477	0.978	.017	5	view →
UCEC	DFS	Tertile	III,IV	1.000	0.515	.042	4	view →
GBM	OS	Median	All	0.765	0.859	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

INPPL1–HNSC (DFS)

Open the HNSC breakdown →