INPPL1

Across TCGA patient cohorts, INPPL1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INPPL1-associated genes across cancer lineages are TAZ, ATM, and Src. Each is linked with INPPL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both INPPL1-to-partner and partner-to-INPPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAZ grouped by INPPL1-low versus INPPL1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPPL1→partner) and Y-score (partner→INPPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TAZ →	+0.222	+2.820	.002	.035	3	4
UCEC	ATM →	-0.427	-2.308	<.001	.005	3	4
SKCM	Src →	-0.243	-3.000	.022	.035	3	3
COAD	MSH2 →	-0.292	-1.991	.001	.031	3	3
COAD	PKC-b-II_pS660 →	-0.360	-3.000	.012	.034	3	3
COAD	Smad4 →	+0.112	+2.321	.036	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

TAZ by INPPL1 expression — SKCM

Explore this box plot interactively →