Across TCGA pan-cancer cohorts, INPP5F mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INPP5F data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher INPP5F mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated INPP5F expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where INPP5F mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.879	0.598	.001	30	view →
LUAD	DFS	Quartile	II,III,IV	0.137	0.678	.021	8	view →
CCRCC	OS	Median	III,IV	0.825	0.578	.014	5	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
UCEC	DFS	Quartile	All	0.962	0.821	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: INPP5F tumor-vs-normal RNA expression · all INPP5F data types