INPP5E

Across TCGA pan-cancer cohorts, INPP5E mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of INPP5E’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where INPP5E mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types INPP5E is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD and LSCC are the cancer types where INPP5E tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INPP5E mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	−0.532	<.001	8	view →
LSCC	All	All	−0.201	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

INPP5E–LUAD

Open the LUAD breakdown →