Across TCGA pan-cancer cohorts, INPP5B Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated INPP5B data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher INPP5B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated INPP5B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, KICH, and UCEC are the cancer types where INPP5B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.088	0.712	<.001	28	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
UCEC	DFS	Median	All	0.973	0.828	.017	8	view →
SKCM	OS	Median	III,IV	0.230	0.721	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: INPP5B tumor-vs-normal RNA expression · all INPP5B data types