Across TCGA pan-cancer cohorts, INPP5B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INPP5B data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher INPP5B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated INPP5B expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where INPP5B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.595	.002	19	view →
PDAC	DFS	Tertile	III,IV	0.324	0.968	.001	17	view →
HNSC	OS	Tertile	All	0.789	0.624	.019	13	view →
LUAD	DFS	Median	All	0.740	0.522	.013	6	view →
CCRCC	DFS	Tertile	II,III,IV	1.000	0.362	.011	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: INPP5B tumor-vs-normal RNA expression · all INPP5B data types