Across TCGA patient cohorts, INPP5B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INPP5B-associated genes across cancer lineages are ATM, Cyclin-B1, and eIF4E. Each is linked with INPP5B in more than 2 cancer types. Because this analysis shows association rather than direction, both INPP5B-to-partner and partner-to-INPP5B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5B→partner) and Y-score (partner→INPP5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.465	-2.415	.001	.003	3	3
UCEC	Cyclin-B1 →	+0.431	+1.652	.020	.006	3	3
UCEC	eIF4E →	+0.200	+2.263	.003	<.001	3	2
UCEC	4E-BP1 →	+0.278	+2.252	.001	.005	3	2
LUSC	PR →	+0.138	+3.009	.037	.019	3	1
UCEC	EGFR_pY1068 →	-0.169	-1.392	.041	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

INPP5B survival (RNA) · tumor vs normal (RNA) · all INPP5B data types