Across TCGA cell cohorts, INPP5B mutation is significantly associated with the drug of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INPP5B-associated genes across cancer lineages are Niraparib, 123829, and 50869. Each is linked with INPP5B in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP5B-to-partner and partner-to-INPP5B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5B→partner) and Y-score (partner→INPP5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.373	+2.646	.036	.047	3	1
LARGE_INTESTINE	123829 →	+0.603	+2.649	.038	.046	3	1
LARGE_INTESTINE	50869 →	+0.457	+2.649	.030	.046	3	1
LARGE_INTESTINE	Sabutoclax →	+0.444	+2.769	.036	.040	3	1
LARGE_INTESTINE	OF-1 →	+0.297	+2.646	.040	.047	2	2
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.531	+2.646	.033	.047	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

INPP5B survival (RNA) · tumor vs normal (RNA) · all INPP5B data types