INPP5A

Across TCGA pan-cancer cohorts, INPP5A Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated INPP5A data layer compared with 23 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher INPP5A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated INPP5A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UVM, UCEC, and LGG are the cancer types where INPP5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.032	0.762	<.001	30	view →
UCEC	DFS	Median	II,III,IV	1.000	0.435	.010	28	view →
LGG	DFS	Median	All	0.110	0.832	<.001	6	view →
LUSC	OS	Median	II,III,IV	0.280	0.742	.037	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
HNSC	OS	Median	IV	0.102	0.733	<.001	6	view →
LIHC	DFS	Median	All	0.092	0.543	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

INPP5A–UVM (DFS)

Open the UVM breakdown →