INPP5A

Across TCGA pan-cancer cohorts, INPP5A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated INPP5A data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher INPP5A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated INPP5A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where INPP5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.246	1.000	.008	28	view →
CCRCC	DFS	Tertile	III,IV	0.806	0.434	.002	20	view →
LUAD	DFS	Median	III,IV	0.621	0.933	.008	6	view →
HNSC	OS	Tertile	All	0.950	1.000	.029	4	view →
PDAC	DFS	Tertile	III,IV	0.821	0.330	.023	3	view →
GBM	DFS	Median	All	0.806	0.632	.008	2	view →
LSCC	DFS	Median	II,III,IV	0.444	0.883	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

INPP5A–UCEC (DFS)

Open the UCEC breakdown →