INPP5A

Across TCGA patient cohorts, INPP5A mutation is significantly associated with the RNA expression of many other genes, with 2,826 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INPP5A-associated genes across cancer lineages are DEFB127, RNA5SP411, and RNU6-383P. Each is linked with INPP5A in more than 2 cancer types. Because this analysis shows association rather than direction, both INPP5A-to-partner and partner-to-INPP5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB127 grouped by INPP5A-low versus INPP5A-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5A→partner) and Y-score (partner→INPP5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	DEFB127 →	+0.057	+4.757	<.001	.004	3	3
UCEC	RNA5SP411 →	+1.205	+2.045	<.001	<.001	3	2
LGG	RNU6-383P →	+0.368	+7.977	<.001	.007	3	2
BLCA	AQP7P2 →	+0.256	+4.304	<.001	.001	3	2
BLCA	TRAJ5 →	+0.624	+3.291	.005	.008	3	2
BLCA	IGHD3-22 →	+1.086	+3.241	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,826 associations by consensus.

DEFB127 by INPP5A expression — CESC

Explore this box plot interactively →