INPP5A

Across TCGA patient cohorts, INPP5A mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INPP5A-associated genes across cancer lineages are ERK2, MEK1, and NF2. Each is linked with INPP5A in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP5A-to-partner and partner-to-INPP5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by INPP5A-low versus INPP5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5A→partner) and Y-score (partner→INPP5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.159	+2.459	.027	.018	3	2
UCEC	MEK1 →	+0.351	+2.906	.010	.001	3	2
UCEC	NF2 →	+0.207	+1.415	.011	.046	3	2
UCEC	Shc_pY317 →	-0.156	-2.169	.006	.003	3	2
UCEC	C-Raf →	+0.251	+2.662	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.257	-2.584	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ERK2 by INPP5A expression — UCEC

Explore this box plot interactively →