INPP5A

Across TCGA cell cohorts, INPP5A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,400 significant associations in total. BONE shows the largest number of these associations.

The most reproducible INPP5A-associated GO terms across cancer lineages are Phosphatidylinositol metabolic process, Positive regulation of substrate adhesion-dependent cell spreading, and Regulation of focal adhesion assembly. Each is linked with INPP5A in more than 11 cancer types. Because this analysis shows association rather than direction, both INPP5A-to-partner and partner-to-INPP5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol metabolic process grouped by INPP5A-low versus INPP5A-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5A→partner) and Y-score (partner→INPP5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Phosphatidylinositol metabolic process →	+0.060	+0.780	<.001	<.001	3	12
BONE	Positive regulation of substrate adhesion-dependent cell spreading →	+0.135	+0.930	<.001	<.001	3	10
BONE	Regulation of focal adhesion assembly →	+0.108	+0.644	.004	.001	3	9
BONE	Dephosphorylation →	+0.049	+0.936	.001	<.001	3	9
OVARY	Negative regulation of smoothened signaling pathway →	+0.068	+0.782	<.001	<.001	3	9
BONE	Regulation of cell-substrate junction assembly →	+0.108	+0.644	.004	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,400 associations by consensus.

Phosphatidylinositol metabolic process by INPP5A expression — PANCREAS

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