INPP5A

Across TCGA cell cohorts, INPP5A mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INPP5A-associated genes across cancer lineages are LIPM, ACER1, and BPIFA1. Each is linked with INPP5A in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP5A-to-partner and partner-to-INPP5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIPM grouped by INPP5A-low versus INPP5A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5A→partner) and Y-score (partner→INPP5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LIPM →	+0.056	+4.930	<.001	.008	3	1
LARGE_INTESTINE	ACER1 →	+0.066	+3.145	.009	.004	3	1
LARGE_INTESTINE	BPIFA1 →	+0.145	+2.688	<.001	.008	3	1
LARGE_INTESTINE	TECRL →	+0.011	+3.240	<.001	.004	3	1
LARGE_INTESTINE	L3MBTL4 →	+0.594	+3.285	.006	.007	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

LIPM by INPP5A expression — SOFT_TISSUE

Explore this box plot interactively →