INPP4B

Across TCGA pan-cancer cohorts, INPP4B mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of INPP4B’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where INPP4B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types INPP4B is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

PDAC, HNSC, and LSCC are the cancer types where INPP4B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INPP4B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	+1.075	<.001	9	view →
HNSC	Male	All	−0.332	<.001	7	view →
LSCC	Male	II,III,IV	−0.918	<.001	6	view →
OV	All	All	−0.777	.029	2	view →
COAD	All	II,III,IV	−0.132	.037	2	view →
CCRCC	All	All	+0.095	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

INPP4B–PDAC

Open the PDAC breakdown →