INPP1

Across TCGA pan-cancer cohorts, INPP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INPP1 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher INPP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated INPP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where INPP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.481	0.256	.007	39	view →
LSCC	OS	Tertile	II,III,IV	0.511	0.950	<.001	24	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	7	view →
HNSC	OS	Median	All	1.000	0.484	.038	6	view →
GBM	OS	Quartile	All	0.281	0.701	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

INPP1–PDAC (OS)

Open the PDAC breakdown →