INPP1

Across TCGA patient cohorts, INPP1 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INPP1-associated genes across cancer lineages are Pericytes, pDC, and Th2 cells. Each is linked with INPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP1-to-partner and partner-to-INPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pericytes grouped by INPP1-low versus INPP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP1→partner) and Y-score (partner→INPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Pericytes →	+0.028	+2.376	.044	.007	3	2
UCEC	pDC →	+0.100	+3.332	<.001	.005	3	1
UCEC	Th2 cells →	+0.211	+2.815	.026	.036	3	1
UCEC	Erythrocytes →	+0.033	+3.071	.010	.017	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Pericytes by INPP1 expression — UCEC

Explore this box plot interactively →