INO80D

Across TCGA patient cohorts, INO80D mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INO80D-associated genes across cancer lineages are INPP4B, JNK_pT183_Y185, and Annexin_VII. Each is linked with INO80D in more than 1 cancer types. Because this analysis shows association rather than direction, both INO80D-to-partner and partner-to-INO80D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by INO80D-low versus INO80D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INO80D→partner) and Y-score (partner→INO80D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.279	-2.459	.027	.018	3	2
UCEC	JNK_pT183_Y185 →	-0.191	-3.169	.003	.018	3	2
UCEC	Annexin_VII →	-0.118	-2.312	.030	.034	3	2
UCEC	ASNS →	+0.348	+2.115	.014	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.575	+2.242	.013	.005	3	2
UCEC	EGFR_pY1068 →	-0.258	-1.584	.008	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

INPP4B by INO80D expression — UCEC

Explore this box plot interactively →