INO80D

Across TCGA cell cohorts, INO80D mutation is significantly associated with the RNA expression of many other genes, with 567 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INO80D-associated genes across cancer lineages are PRSS50, SET, and HELLS. Each is linked with INO80D in more than 2 cancer types. Because this analysis shows association rather than direction, both INO80D-to-partner and partner-to-INO80D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS50 grouped by INO80D-low versus INO80D-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INO80D→partner) and Y-score (partner→INO80D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRSS50 →	+0.060	+4.070	.001	.004	3	2
LARGE_INTESTINE	SET →	+0.509	+3.502	<.001	.001	3	2
LARGE_INTESTINE	HELLS →	+0.938	+3.067	<.001	.009	3	2
LARGE_INTESTINE	SNX7 →	+0.663	+3.330	.005	.002	3	2
LARGE_INTESTINE	SGCB →	+0.854	+3.502	.006	.001	3	2
LARGE_INTESTINE	STOX1 →	+1.083	+3.502	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 567 associations by consensus.

PRSS50 by INO80D expression — BLOOD_Lymphoma

Explore this box plot interactively →