INO80B

Across TCGA patient cohorts, INO80B mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INO80B-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ACVRL1. Each is linked with INO80B in more than 1 cancer types. Because this analysis shows association rather than direction, both INO80B-to-partner and partner-to-INO80B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by INO80B-low versus INO80B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INO80B→partner) and Y-score (partner→INO80B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.111	-3.143	.011	.018	3	1
UCEC	EGFR_pY1068 →	-0.241	-2.115	.028	.019	3	1
UCEC	ACVRL1 →	-0.165	-2.439	.005	.019	3	1
UCEC	Paxillin →	+0.223	+2.469	.048	.010	3	1
UCEC	P-Cadherin →	-0.151	-3.169	.016	.018	3	1
UCEC	PCNA →	+0.224	+3.459	.017	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

14-3-3_beta by INO80B expression — UCEC

Explore this box plot interactively →