Across TCGA pan-cancer cohorts, INKA2-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated INKA2-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher INKA2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated INKA2-AS1 expression acts as an unfavorable survival marker, although some lineages such as CESC and LGG show a favorable association.

ACC, COAD, and MESO are the cancer types where INKA2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.401	0.831	<.001	91	view →
COAD	DFS	Median	All	0.407	0.650	.003	80	view →
MESO	OS	Median	II,III,IV	0.301	0.744	.002	51	view →
LIHC	OS	Median	All	0.439	0.570	<.001	48	view →
CESC	OS	Median	II,III,IV	0.926	0.721	<.001	42	view →
KICH	DFS	Median	III,IV	0.240	1.000	.001	26	view →
LGG	OS	Median	All	0.939	0.834	.001	24	view →
BLCA	OS	Tertile	All	0.240	0.616	.013	20	view →
UVM	DFS	Median	III,IV	0.374	0.689	.010	19	view →
PCPG	DFS	Quartile	All	0.530	0.957	.005	18	view →
HNSC	DFS	Median	II,III,IV	0.418	0.269	.008	18	view →
PAAD	DFS	Tertile	All	0.501	0.251	.014	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

Exploration

Same gene, other analysis: INKA2-AS1 tumor-vs-normal RNA expression · all INKA2-AS1 data types