INIP

Across TCGA pan-cancer cohorts, INIP RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated INIP data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher INIP RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated INIP expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

KIRC, ACC, and COAD are the cancer types where INIP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.745	0.522	<.001	109	view →
ACC	DFS	Median	All	0.369	0.778	<.001	93	view →
COAD	OS	Quartile	All	0.922	0.682	.003	30	view →
BRCA	OS	Quartile	IV	0.986	0.216	.002	22	view →
KIRP	DFS	Median	All	0.977	0.800	.010	22	view →
MESO	OS	Quartile	II,III,IV	0.327	0.562	.027	20	view →
SCLC	DFS	Tertile	II,III,IV	0.563	0.245	.007	19	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
THYM	DFS	Quartile	II,III,IV	0.919	0.568	.006	16	view →
UVM	DFS	Quartile	III,IV	0.235	0.806	.010	13	view →
LUAD	DFS	Tertile	IV	0.896	0.176	.013	13	view →
THCA	DFS	Quartile	All	0.920	0.787	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

INIP–KIRC (DFS)

Open the KIRC breakdown →