INHBE

Across TCGA patient cohorts, INHBE mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INHBE-associated genes across cancer lineages are Rad50, EGFR_pY1068, and EGFR. Each is linked with INHBE in more than 1 cancer types. Because this analysis shows association rather than direction, both INHBE-to-partner and partner-to-INHBE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by INHBE-low versus INHBE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INHBE→partner) and Y-score (partner→INHBE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.251	-2.115	.017	.019	3	2
UCEC	EGFR_pY1068 →	-0.328	-3.584	.002	.002	3	1
UCEC	EGFR →	-0.222	-2.295	.001	.033	3	1
UCEC	eIF4E →	+0.190	+3.013	.039	.018	3	1
UCEC	FoxM1 →	+0.253	+3.906	.025	<.001	3	1
UCEC	Ku80 →	+0.254	+1.598	.013	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Rad50 by INHBE expression — UCEC

Explore this box plot interactively →