INHBE

Across TCGA cell cohorts, INHBE mutation is significantly associated with the mutation status of many other genes, with 2,381 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INHBE-associated genes across cancer lineages are CCDC33, KSR2, and RHAG. Each is linked with INHBE in more than 2 cancer types. Because this analysis shows association rather than direction, both INHBE-to-partner and partner-to-INHBE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC33 grouped by INHBE-low versus INHBE-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INHBE→partner) and Y-score (partner→INHBE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CCDC33 →	+4.437	+5.000	.007	.007	1	3
BONE	KSR2 →	+5.437	+5.437	.003	.003	1	3
BONE	RHAG →	+5.437	+5.437	.003	.003	1	3
BONE	SCN2A →	+4.437	+5.000	.007	.007	1	3
LUNG_NSCLC_LUAD	CADPS →	+2.681	+2.906	.005	.005	1	3
LUNG_NSCLC_LUAD	YEATS2 →	+3.851	+3.263	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,381 associations by consensus.

CCDC33 by INHBE expression — BONE

Explore this box plot interactively →