INHBA

Across TCGA patient cohorts, INHBA mutation is significantly associated with the RNA expression of many other genes, with 5,222 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INHBA-associated genes across cancer lineages are NDUFC1, FAM177A1, and CALHM6. Each is linked with INHBA in more than 2 cancer types. Because this analysis shows association rather than direction, both INHBA-to-partner and partner-to-INHBA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFC1 grouped by INHBA-low versus INHBA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INHBA→partner) and Y-score (partner→INHBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFC1 →	+0.343	+1.776	<.001	<.001	3	3
SKCM	FAM177A1 →	+0.420	+2.807	.001	.003	3	3
UCEC	CALHM6 →	+0.657	+1.652	.004	.005	3	3
UCEC	RAP2A →	+0.464	+1.765	.002	<.001	3	3
UCEC	PCID2 →	+0.292	+2.917	.007	<.001	3	3
UCEC	ADAMDEC1 →	+0.675	+1.541	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,222 associations by consensus.

NDUFC1 by INHBA expression — UCEC

Explore this box plot interactively →